CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01702
Pert ID:	BRD-K24023109
Compound Name:	diltiazem
Targets:	CACNA1C\|CACNA1S\|CACNA2D1\|CACNG1\|HTR3A\|KCNA5
MoA:	calcium channel blocker
SMILES:	COc1ccc(cc1)[C@@H]1Sc2ccccc2N(CCN(C)C)C(=O)[C@@H]1OC(C)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2854	BRD-K24023109	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.23
3165	BRD-K24023109	HCC515	10 uM	24 h	0.0	0.0	0.0	0.31	1.11	0.71
3753	BRD-K24023109	VCAP	10 uM	24 h	0.2	0.84	0.0	0.0	0.0	0.0
44344	BRD-K24023109	A375	10 uM	6 h	0.2	0.82	0.0	0.24	0.86	0.15
44551	BRD-K24023109	A549	10 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.24
44902	BRD-K24023109	ASC	10 uM	24 h	0.27	1.13	0.29	0.35	1.23	1.19
45205	BRD-K24023109	HEPG2	10 uM	6 h	0.17	0.71	0.0	0.3	1.06	0.59
45471	BRD-K24023109	HT29	10 uM	6 h	0.23	0.97	0.08	0.26	0.92	0.26
46020	BRD-K24023109	NPC	10 uM	24 h	0.0	0.0	0.0	0.29	1.04	0.55
46338	BRD-K24023109	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46655	BRD-K24023109	SKB	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.94	0.39
51333	BRD-K24023109	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.96	0.44
51448	BRD-K24023109	PC3	10 uM	24 h	0.27	1.12	0.27	-0.25	-0.85	0.19
91031	BRD-K24023109	HUH7	8 uM	72 h	0.3	1.25	0.56	0.22	0.79	0.08
99765	BRD-K24023109	U2OS	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary