CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01745
Pert ID:	BRD-A29734509
Compound Name:	disopyramide
Targets:	CHRM1\|CHRM2\|CHRM3\|KCND2\|KCND3\|KCNH2\|SCN5A
MoA:	sodium channel blocker
SMILES:	CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5511	BRD-A29734509	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29
6459	BRD-A29734509	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42193	BRD-A29734509	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42538	BRD-A29734509	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
43394	BRD-A29734509	NPC	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.13
43708	BRD-A29734509	PHH	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
51205	BRD-A29734509	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119956	BRD-A29734509	A375	0.125 uM	24 h	0.0	0.0	0.0	0.26	0.94	0.28
120000	BRD-A29734509	A549	10 uM	24 h	0.38	1.59	1.52	0.27	0.94	0.3
120061	BRD-A29734509	HELA	0.125 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.6
120116	BRD-A29734509	HT29	3.33 uM	24 h	-0.2	-0.84	0.01	-0.36	-1.2	1.16
120193	BRD-A29734509	PC3	0.04 uM	24 h	0.0	0.0	0.0	0.26	0.92	0.25
128819	BRD-A29734509	HA1E	0.01 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
128881	BRD-A29734509	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary