CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01746
Pert ID:	BRD-K32744045
Compound Name:	disulfiram
Targets:	ALDH2\|DBH
MoA:	aldehyde dehydrogenase inhibitor; DNA methyltransferase inhibitor; TRPV agonist
SMILES:	CCN(CC)C(=S)SSC(=S)N(CC)CC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
24666	BRD-K32744045	A549	10 uM	6 h	-0.26	-1.07	0.28	-0.44	-1.46	15.35
24764	BRD-K32744045	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
24895	BRD-K32744045	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25501	BRD-K32744045	VCAP	10 uM	6 h	-0.26	-1.07	0.27	0.0	0.0	0.0
51276	BRD-K32744045	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
52858	BRD-K32744045	HEPG2	40 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
53188	BRD-K32744045	MCF10A	30 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91244	BRD-K32744045	HUH7	12 uM	72 h	-0.31	-1.31	0.82	-0.27	-0.89	0.27
96551	BRD-K32744045	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97171	BRD-K32744045	A375	1.11 uM	24 h	0.0	0.0	0.0	-0.45	-1.51	15.35
99848	BRD-K32744045	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
120633	BRD-K32744045	HELA	10 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
120706	BRD-K32744045	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120812	BRD-K32744045	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136400	BRD-K32744045	SHSY5Y	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary