CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01766
Pert ID:	BRD-K30577245
Compound Name:	docetaxel
Targets:	BCL2\|MAP2\|MAP4\|MAPT\|NR1I2\|TUBB\|TUBB1
MoA:	tubulin polymerization inhibitor
SMILES:	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
87291	BRD-K30577245	BJAB	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87369	BRD-K30577245	HBL1	0.66 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.65
87419	BRD-K30577245	K562	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87466	BRD-K30577245	KMS34	0.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87489	BRD-K30577245	MINO	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87571	BRD-K30577245	NALM6	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87621	BRD-K30577245	OCILY10	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87671	BRD-K30577245	OCILY19	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87722	BRD-K30577245	OCILY3	0.125 uM	24 h	0.24	1.0	0.1	0.0	0.0	0.0
87770	BRD-K30577245	SKMEL5	2.5 uM	24 h	0.0	0.0	0.0	-0.36	-1.2	1.16
87793	BRD-K30577245	THP1	0.66 uM	24 h	0.0	0.0	0.0	-0.24	-0.79	0.11
87837	BRD-K30577245	TMD8	0.125 uM	24 h	-0.26	-1.07	0.27	-0.23	-0.79	0.1
91088	BRD-K30577245	HUH7	4 uM	72 h	-0.22	-0.94	0.07	-0.28	-0.93	0.35

Summary