CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01776
Pert ID:	BRD-K36386086
Compound Name:	dolutegravir
Targets:	CYP3A4\|CYP3A5\|CYP3A7\|POU2F2\|UGT1A1
MoA:	HIV integrase inhibitor
SMILES:	C[C@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
120536	BRD-K36386086	A375	3.33 uM	24 h	-0.2	-0.84	0.01	0.39	1.39	2.17
120582	BRD-K36386086	A549	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120639	BRD-K36386086	HELA	3.33 uM	3 h	0.22	0.93	0.05	0.0	0.0	0.0
120687	BRD-K36386086	HT29	10 uM	24 h	-0.15	-0.6	0.0	0.2	0.71	0.02
120741	BRD-K36386086	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120794	BRD-K36386086	PC3	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120849	BRD-K36386086	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129016	BRD-K36386086	HA1E	0.25 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
129073	BRD-K36386086	MCF??7.00	0.25 uM	24 h	0.0	0.0	0.0	0.26	0.92	0.25

Summary