CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01779
Pert ID:	BRD-A49160188
Compound Name:	donepezil
Targets:	ACHE\|HTR2A
MoA:	acetylcholinesterase inhibitor
SMILES:	COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5404	BRD-A49160188	HA1E	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.08	0.78
5523	BRD-A49160188	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.35	2.02
5842	BRD-A49160188	HEPG2	10 uM	6 h	-0.33	-1.37	1.08	0.0	0.0	0.0
6135	BRD-A49160188	PC3	10 uM	24 h	-0.24	-1.0	0.14	-0.28	-0.93	0.35
6406	BRD-A49160188	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37082	BRD-A49160188	A375	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.07	0.75
37242	BRD-A49160188	A549	10 uM	24 h	0.28	1.19	0.41	0.27	0.95	0.31
37510	BRD-A49160188	ASC	10 uM	24 h	-0.25	-1.05	0.24	0.2	0.69	0.01
38359	BRD-A49160188	NPC	10 uM	24 h	-0.23	-0.95	0.08	0.0	0.0	0.0
125326	BRD-A49160188	HEK293	0.125 uM	24 h	-0.24	-1.0	0.15	0.0	0.0	0.0
125407	BRD-A49160188	JURKAT	10 uM	24 h	-0.23	-0.95	0.09	-0.31	-1.03	0.64
125454	BRD-A49160188	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	-0.4	-1.36	2.02
133430	BRD-A49160188	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133460	BRD-A49160188	HT29	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133525	BRD-A49160188	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133562	BRD-A49160188	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133609	BRD-A49160188	THP1	2.22 uM	24 h	0.29	1.2	0.44	0.29	1.04	0.53
133640	BRD-A49160188	YAPC	0.08 uM	24 h	0.0	0.0	0.0	-0.37	-1.25	1.35

Summary