CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01786
Pert ID:	BRD-K71075609
Compound Name:	dorzolamide
Targets:	CA1\|CA12\|CA14\|CA2\|CA4\|CA7
MoA:	carbonic anhydrase inhibitor
SMILES:	CCN[C@@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126631	BRD-K71075609	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126723	BRD-K71075609	HELA	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126745	BRD-K71075609	HT29	10 uM	24 h	0.22	0.93	0.05	0.2	0.69	0.01
126784	BRD-K71075609	JURKAT	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126846	BRD-K71075609	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126916	BRD-K71075609	PC3	10 uM	24 h	0.24	1.02	0.13	-0.22	-0.75	0.06
126958	BRD-K71075609	THP1	0.37 uM	24 h	0.0	0.0	0.0	0.3	1.06	0.6
134705	BRD-K71075609	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134733	BRD-K71075609	HA1E	2.22 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.6
134768	BRD-K71075609	HEK293	0.74 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.93
134872	BRD-K71075609	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.12
134930	BRD-K71075609	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.88
134944	BRD-K71075609	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.35
134994	BRD-K71075609	YAPC	0.74 uM	24 h	0.2	0.84	0.0	-0.3	-0.99	0.51

Summary