CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01791
Pert ID:	BRD-K37694030
Compound Name:	doxepin
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD2\|HRH1\|HRH2\|HRH4\|HTR1A\|HTR2A\|HTR2B\|HTR2C\|HTR6\|KCNH2\|SLC6A2\|SLC6A4
MoA:	histamine receptor antagonist
SMILES:	CN(C)CC\C=C1\c2ccccc2COc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5448	BRD-K37694030	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5771	BRD-K37694030	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
6185	BRD-K37694030	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25362	BRD-K37694030	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41931	BRD-K37694030	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42358	BRD-K37694030	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42684	BRD-K37694030	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
43548	BRD-K37694030	NPC	10 uM	24 h	0.32	1.35	0.96	0.0	0.0	0.0
43846	BRD-K37694030	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44114	BRD-K37694030	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123595	BRD-K37694030	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123710	BRD-K37694030	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123732	BRD-K37694030	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123776	BRD-K37694030	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131996	BRD-K37694030	A375	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132047	BRD-K37694030	HELA	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132065	BRD-K37694030	HT29	0.01 uM	24 h	0.29	1.21	0.47	-0.4	-1.34	1.86

Summary