CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01848
Pert ID:	BRD-A51820102
Compound Name:	econazole
Targets:	CYP51A1\|NPY1R\|NPY2R\|TRPM2\|TRPV5
MoA:	lanosterol demethylase inhibitor; sterol demethylase inhibitor
SMILES:	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4526	BRD-A51820102	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5001	BRD-A51820102	VCAP	10 uM	6 h	0.0	0.0	0.0	0.4	1.41	2.18
37515	BRD-A51820102	ASC	10 uM	24 h	0.23	0.98	0.08	0.0	0.0	0.0
37829	BRD-A51820102	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38364	BRD-A51820102	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38647	BRD-A51820102	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38870	BRD-A51820102	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
100207	BRD-A51820102	U2OS	10 uM	6 h	-0.28	-1.15	0.44	-0.36	-1.22	1.24
124271	BRD-A51820102	A375	10 uM	24 h	0.22	0.9	0.02	-0.3	-1.0	0.54
124285	BRD-A51820102	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124296	BRD-A51820102	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124314	BRD-A51820102	HEK293	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.85	0.2
124343	BRD-A51820102	HELA	10 uM	24 h	0.19	0.79	0.0	-0.32	-1.07	0.75
124379	BRD-A51820102	HT29	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.39
124404	BRD-A51820102	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.3	1.06	0.6
124445	BRD-A51820102	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.39	1.37	2.0
124461	BRD-A51820102	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.75
124481	BRD-A51820102	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124510	BRD-A51820102	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124537	BRD-A51820102	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132592	BRD-A51820102	THP1	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary