CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00188
Pert ID:	BRD-K75295174
Compound Name:	alisertib
Targets:	AURKA
MoA:	Aurora kinase inhibitor
SMILES:	COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
84313	BRD-K75295174	A549	20 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
85023	BRD-K75295174	A375	10 uM	24 h	-0.24	-0.99	0.14	-0.36	-1.21	1.24
85428	BRD-K75295174	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
86098	BRD-K75295174	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.35
95706	BRD-K75295174	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95994	BRD-K75295174	PHH	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
116880	BRD-K75295174	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119608	BRD-K75295174	MCF??7.00	3.33 uM	24 h	0.29	1.22	0.48	-0.43	-1.46	15.35
127064	BRD-K75295174	HEK293	1.11 uM	24 h	0.0	0.0	0.0	0.27	0.97	0.36
127096	BRD-K75295174	HELA	10 uM	24 h	0.0	0.0	0.0	0.23	0.83	0.11
127236	BRD-K75295174	PC3	3.33 uM	24 h	0.0	0.0	0.0	-0.47	-1.58	15.65
127279	BRD-K75295174	THP1	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127310	BRD-K75295174	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135083	BRD-K75295174	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.36	-1.21	1.24
135168	BRD-K75295174	JURKAT	2.22 uM	24 h	0.25	1.05	0.17	-0.29	-0.97	0.47
135204	BRD-K75295174	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135260	BRD-K75295174	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary