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CMap Candidate Details

Structure:
CMap ID: C01909
Pert ID: BRD-K61314889
Compound Name: endo-IWR-1
Targets: TNKS|TNKS2
MoA: PARP inhibitor
SMILES: O=C(Nc1cccc2cccnc12)c1ccc(cc1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9770 BRD-K61314889 H1299 10 uM 6 h 0.27 1.12 0.26 0.0 0.0 0.0
10991 BRD-K61314889 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12092 BRD-K61314889 NCIH596 10 uM 6 h -0.24 -1.0 0.15 0.0 0.0 0.0
12351 BRD-K61314889 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12829 BRD-K61314889 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13649 BRD-K61314889 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90602 BRD-K61314889 HCT116 3.33 uM 24 h -0.2 -0.81 0.0 0.0 0.0 0.0
90696 BRD-K61314889 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
96008 BRD-K61314889 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96709 BRD-K61314889 A375 10 uM 24 h -0.29 -1.19 0.55 0.0 0.0 0.0
98003 BRD-K61314889 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98036 BRD-K61314889 MCF??7.00 3.33 uM 24 h -0.24 -1.01 0.16 -0.27 -0.92 0.32
98087 BRD-K61314889 P1A82 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98764 BRD-K61314889 NPC 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
98917 BRD-K61314889 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117693 BRD-K61314889 A549 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
117786 BRD-K61314889 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117837 BRD-K61314889 HEPG2 10 uM 24 h 0.28 1.17 0.38 0.0 0.0 0.0
117983 BRD-K61314889 PC3 10 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).