CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01915
Pert ID:	BRD-K68488863
Compound Name:	ENMD-2076
Targets:	AURKA\|FLT3\|KDR\|PDGFRA\|PTK2\|SRC
MoA:	Aurora kinase inhibitor; FLT3 inhibitor; VEGFR inhibitor
SMILES:	CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(\C=C\c2ccccc2)n1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
95624	BRD-K68488863	U2OS	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119186	BRD-K68488863	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119215	BRD-K68488863	A549	10 uM	24 h	0.0	0.0	0.0	0.34	1.19	1.03
119274	BRD-K68488863	HCC515	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119303	BRD-K68488863	HEPG2	3.33 uM	24 h	0.0	0.0	0.0	-0.22	-0.75	0.06
119329	BRD-K68488863	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126449	BRD-K68488863	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126527	BRD-K68488863	MCF10A	3.33 uM	24 h	0.21	0.88	0.02	-0.33	-1.1	0.87
126559	BRD-K68488863	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134408	BRD-K68488863	HA1E	0.03 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.17
134436	BRD-K68488863	HELA	2.22 uM	24 h	0.0	0.0	0.0	-0.31	-1.06	0.73
134516	BRD-K68488863	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	-0.4	-1.35	2.02
134573	BRD-K68488863	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.78
134630	BRD-K68488863	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134656	BRD-K68488863	YAPC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary