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CMap Candidate Details

Structure:
CMap ID: C01939
Pert ID: BRD-A98990573
Compound Name: epinastine
Targets: ADRA1A|ADRA2A|HRH1|HRH2|HTR2A|HTR7
MoA: histamine receptor antagonist
SMILES: NC1=NCC2N1c1ccccc1Cc1ccccc21
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127750 BRD-A98990573 A375 0.125 uM 24 h -0.25 -1.04 0.22 -0.34 -1.13 0.98
127795 BRD-A98990573 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127878 BRD-A98990573 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127952 BRD-A98990573 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
128004 BRD-A98990573 MCF10A 0.04 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
128054 BRD-A98990573 PC3 10 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
128085 BRD-A98990573 YAPC 3.33 uM 24 h -0.2 -0.84 0.01 -0.31 -1.05 0.69
135530 BRD-A98990573 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
135579 BRD-A98990573 HELA 0.01 uM 24 h 0.28 1.17 0.38 0.0 0.0 0.0
135621 BRD-A98990573 HT29 2.22 uM 24 h 0.24 0.99 0.09 0.0 0.0 0.0
135670 BRD-A98990573 JURKAT 0.74 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
135702 BRD-A98990573 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).