CMap Candidate Details
Structure:
| CMap ID: | C01949 |
| Pert ID: | BRD-K68164687 |
| Compound Name: | epothilone-b |
| Targets: | TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA4A|TUBA8|TUBB|TUBB1|TUBB3|TUBB4A|TUBB4B |
| MoA: | microtubule stabilizing agent; tubulin polymerization inhibitor |
| SMILES: | C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@@H](OC(=O)C[C@@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 126395 | BRD-K68164687 | HA1E | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126417 | BRD-K68164687 | HEK293 | 0.37 uM | 24 h | 0.24 | 0.99 | 0.1 | 0.0 | 0.0 | 0.0 |
| 126508 | BRD-K68164687 | MCF10A | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126568 | BRD-K68164687 | PC3 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.21 | 1.24 |
| 126590 | BRD-K68164687 | YAPC | 0.125 uM | 24 h | 0.19 | 0.78 | 0.0 | 0.17 | 0.59 | 0.0 |
| 134338 | BRD-K68164687 | A375 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134368 | BRD-K68164687 | A549 | 2.22 uM | 24 h | 0.23 | 0.96 | 0.08 | 0.0 | 0.0 | 0.0 |
| 134418 | BRD-K68164687 | HELA | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134448 | BRD-K68164687 | HT29 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134484 | BRD-K68164687 | HUVEC | 0.08 uM | 24 h | -0.29 | -1.21 | 0.58 | -0.3 | -1.02 | 0.61 |
| 134557 | BRD-K68164687 | MCF??7.00 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.41 | -1.37 | 2.02 |
| 134585 | BRD-K68164687 | MDAMB231 | 2.22 uM | 24 h | -0.27 | -1.1 | 0.36 | -0.26 | -0.87 | 0.24 |