CMap Candidate Details
Structure:
| CMap ID: | C01958 |
| Pert ID: | BRD-K26531771 |
| Compound Name: | EPZ-5676 |
| Targets: | DOT1L |
| MoA: | histone lysine methyltransferase inhibitor |
| SMILES: | CC(C)N(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@@H]1C[C@H](CCc2nc3cc(ccc3[nH]2)C(C)(C)C)C1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 90843 | BRD-K26531771 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.21 | 1.24 |
| 96711 | BRD-K26531771 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.07 | 0.75 |
| 96759 | BRD-K26531771 | PC3 | 1.11 uM | 24 h | -0.31 | -1.27 | 0.74 | 0.0 | 0.0 | 0.0 |