CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01968
Pert ID:	BRD-A25004090
Compound Name:	erastin
Targets:	VDAC2
MoA:	ion channel antagonist
SMILES:	CCOc1ccccc1-n1c(=O)c2ccccc2nc1C(C)N1CCN(CC1)C(=O)COc1ccc(Cl)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
8866	BRD-A25004090	A375	4 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
9279	BRD-A25004090	AGS	4 uM	6 h	0.26	1.1	0.24	0.38	1.35	1.72
9584	BRD-A25004090	H1299	4 uM	6 h	0.27	1.11	0.25	0.0	0.0	0.0
9940	BRD-A25004090	HA1E	4 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.05
10391	BRD-A25004090	HCT116	4 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10900	BRD-A25004090	HT29	4 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
11332	BRD-A25004090	NCIH2073	4 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11647	BRD-A25004090	NCIH508	4 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12513	BRD-A25004090	PC3	4 uM	24 h	-0.24	-0.99	0.13	-0.26	-0.88	0.24
12657	BRD-A25004090	SW480	4 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13137	BRD-A25004090	U937	4 uM	6 h	0.0	0.0	0.0	0.3	1.08	0.65
13529	BRD-A25004090	VCAP	4 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
96223	BRD-A25004090	U2OS	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119418	BRD-A25004090	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119479	BRD-A25004090	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.65
119516	BRD-A25004090	HEPG2	10 uM	24 h	0.0	0.0	0.0	-0.39	-1.33	1.72
119584	BRD-A25004090	MCF??7.00	10 uM	24 h	0.25	1.05	0.18	-0.34	-1.15	1.07

Summary