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CMap Candidate Details

Structure:
CMap ID: C01978
Pert ID: BRD-K70401845
Compound Name: erlotinib
Targets: EGFR|NR1I2
MoA: EGFR inhibitor
SMILES: COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
10 BRD-K70401845 NCIH2073 2.5 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
18 BRD-K70401845 NCIH508 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
27 BRD-K70401845 NCIH596 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
1316 BRD-K70401845 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
34162 BRD-K70401845 ASC 10 uM 24 h -0.29 -1.22 0.62 0.0 0.0 0.0
34942 BRD-K70401845 HEPG2 10 uM 6 h -0.24 -1.0 0.14 -0.32 -1.08 0.8
35608 BRD-K70401845 NEU 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
35828 BRD-K70401845 NPC 10 uM 24 h -0.34 -1.41 1.41 0.0 0.0 0.0
36329 BRD-K70401845 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36626 BRD-K70401845 SKB 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.19
36857 BRD-K70401845 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87283 BRD-K70401845 BJAB 10 uM 24 h -0.27 -1.12 0.38 -0.33 -1.11 0.91
87338 BRD-K70401845 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87387 BRD-K70401845 K562 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
87436 BRD-K70401845 KMS34 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
87497 BRD-K70401845 MINO 10 uM 3 h 0.0 0.0 0.0 -0.34 -1.13 1.0
87539 BRD-K70401845 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87589 BRD-K70401845 OCILY10 10 uM 24 h 0.22 0.9 0.02 -0.36 -1.2 1.16
87640 BRD-K70401845 OCILY19 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
87690 BRD-K70401845 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87739 BRD-K70401845 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
87783 BRD-K70401845 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
87827 BRD-K70401845 TMD8 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90776 BRD-K70401845 HPTEC 1.11 uM 24 h 0.18 0.73 0.0 0.0 0.0 0.0
91284 BRD-K70401845 HUH7 1.11 uM 72 h 0.0 0.0 0.0 0.25 0.88 0.18
92029 BRD-K70401845 BT20 3.33 uM 24 h -0.3 -1.26 0.72 0.0 0.0 0.0
92146 BRD-K70401845 HS578T 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92376 BRD-K70401845 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118484 BRD-K70401845 HA1E 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
118529 BRD-K70401845 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126361 BRD-K70401845 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126430 BRD-K70401845 HEK293 10 uM 24 h -0.35 -1.47 1.43 0.0 0.0 0.0
126472 BRD-K70401845 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126491 BRD-K70401845 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126518 BRD-K70401845 MCF10A 0.37 uM 24 h -0.33 -1.36 1.06 0.0 0.0 0.0
126552 BRD-K70401845 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
126597 BRD-K70401845 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134371 BRD-K70401845 A549 2.22 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
134496 BRD-K70401845 HUVEC 0.01 uM 24 h -0.29 -1.21 0.6 0.0 0.0 0.0
134565 BRD-K70401845 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.36
134620 BRD-K70401845 PC3 0.25 uM 24 h 0.22 0.91 0.03 0.3 1.07 0.63
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).