CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02003
Pert ID:	BRD-K00077635
Compound Name:	estramustine-phosphate
Targets:	ESR1\|ESR2\|MAP1A\|MAP2
MoA:	DNA synthesis inhibitor; microtubule inhibitor
SMILES:	C[C@]12CC[C@H]3[C@@H](CCc4cc(OC(=O)N(CCCl)CCCl)ccc34)[C@@H]1CC[C@@H]2OP(O)(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
122827	BRD-K00077635	A375	0.37 uM	24 h	-0.27	-0.89	0.27
122871	BRD-K00077635	HEK293	0.04 uM	24 h	-0.24	-0.8	0.12
122925	BRD-K00077635	HELA	0.04 uM	24 h	0.0	0.0	0.0
122956	BRD-K00077635	HT29	10 uM	24 h	-0.4	-1.36	2.02
122996	BRD-K00077635	JURKAT	3.33 uM	24 h	0.0	0.0	0.0
123050	BRD-K00077635	MCF10A	10 uM	24 h	0.0	0.0	0.0
123068	BRD-K00077635	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0
123085	BRD-K00077635	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0
123157	BRD-K00077635	THP1	0.125 uM	24 h	0.0	0.0	0.0
131223	BRD-K00077635	A549	2.22 uM	24 h	0.0	0.0	0.0
131266	BRD-K00077635	HA1E	0.08 uM	24 h	0.0	0.0	0.0
131333	BRD-K00077635	HUVEC	0.25 uM	24 h	0.0	0.0	0.0
131450	BRD-K00077635	PC3	2.22 uM	24 h	0.0	0.0	0.0
131478	BRD-K00077635	YAPC	2.22 uM	24 h	0.0	0.0	0.0

Summary