CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02005
Pert ID:	BRD-K81839095
Compound Name:	estrone
Targets:	ESR1\|ESR2
MoA:	estrogen receptor agonist; estrogenic hormone
SMILES:	C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4145	BRD-K81839095	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5129	BRD-K81839095	VCAP	10 uM	6 h	-0.19	-0.81	0.0	-0.28	-0.94	0.36
37745	BRD-K81839095	ASC	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.27	1.44
37948	BRD-K81839095	HEPG2	10 uM	6 h	-0.21	-0.87	0.02	0.0	0.0	0.0
38109	BRD-K81839095	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38561	BRD-K81839095	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39011	BRD-K81839095	SKB	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.19	1.16
53258	BRD-K81839095	MCF10A	12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91283	BRD-K81839095	HUH7	12.5 uM	72 h	0.33	1.36	0.97	-0.34	-1.15	1.08
98938	BRD-K81839095	NEU	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.33	1.83
119188	BRD-K81839095	A375	10 uM	24 h	0.19	0.77	0.0	0.0	0.0	0.0
119217	BRD-K81839095	A549	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119276	BRD-K81839095	HCC515	10 uM	24 h	0.23	0.95	0.07	0.0	0.0	0.0
119354	BRD-K81839095	MCF??7.00	10 uM	24 h	0.29	1.21	0.46	-0.35	-1.19	1.16
119379	BRD-K81839095	PC3	0.12 uM	24 h	-0.21	-0.86	0.02	0.0	0.0	0.0

Summary