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CMap Candidate Details

Structure:
CMap ID: C02012
Pert ID: BRD-K64755930
Compound Name: etazolate
Targets: GABRB3|PDE4A
MoA: phosphodiesterase inhibitor
SMILES: CCOC(=O)c1cnc2n(CC)ncc2c1NN=C(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6795 BRD-K64755930 A375 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
7478 BRD-K64755930 HA1E 10 uM 6 h 0.27 1.11 0.26 0.0 0.0 0.0
7706 BRD-K64755930 HCC515 10 uM 6 h 0.0 0.0 0.0 0.21 0.73 0.03
8528 BRD-K64755930 PC3 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.25 1.35
8842 BRD-K64755930 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.06 0.75
91371 BRD-K64755930 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99337 BRD-K64755930 U2OS 10 uM 6 h 0.0 0.0 0.0 0.24 0.85 0.15
125056 BRD-K64755930 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125078 BRD-K64755930 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125115 BRD-K64755930 MDAMB231 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
125171 BRD-K64755930 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125213 BRD-K64755930 YAPC 10 uM 24 h 0.24 1.0 0.11 -0.27 -0.91 0.31
132998 BRD-K64755930 A549 2.22 uM 24 h -0.2 -0.81 0.0 -0.19 -0.65 0.01
133059 BRD-K64755930 HEK293 0.74 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
133094 BRD-K64755930 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.87
133166 BRD-K64755930 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133231 BRD-K64755930 MCF??7.00 0.03 uM 24 h 0.31 1.29 0.64 -0.34 -1.13 0.99
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).