CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02057
Pert ID:	BRD-K54770957
Compound Name:	etoricoxib
Targets:	PTGS2
MoA:	cyclooxygenase inhibitor
SMILES:	Cc1ccc(cn1)-c1ncc(Cl)cc1-c1ccc(cc1)S(C)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91196	BRD-K54770957	HUH7	10 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
124304	BRD-K54770957	HA1E	10 uM	24 h	0.17	0.71	0.0	-0.26	-0.89	0.26
124388	BRD-K54770957	HT29	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.25
124425	BRD-K54770957	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124492	BRD-K54770957	MDAMB231	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124522	BRD-K54770957	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132336	BRD-K54770957	A375	0.08 uM	24 h	0.0	0.0	0.0	0.34	1.22	1.15
132363	BRD-K54770957	A549	2.22 uM	24 h	-0.31	-1.28	0.76	-0.23	-0.77	0.08
132428	BRD-K54770957	HEK293	0.25 uM	24 h	-0.25	-1.03	0.19	0.25	0.9	0.21
132447	BRD-K54770957	HELA	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132499	BRD-K54770957	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	-0.31	-1.06	0.73
132527	BRD-K54770957	MCF??7.00	2.22 uM	24 h	-0.35	-1.45	1.43	0.34	1.19	1.01
132613	BRD-K54770957	THP1	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132645	BRD-K54770957	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary