CMap Candidate Details
Structure:
| CMap ID: | C02062 |
| Pert ID: | BRD-K74717603 |
| Compound Name: | etravirine |
| Targets: | CYP2C19|CYP2C9|CYP3A4 |
| MoA: | non-nucleoside reverse transcriptase inhibitor |
| SMILES: | Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 127357 | BRD-K74717603 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.43 | -1.46 | 15.35 |
| 127431 | BRD-K74717603 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127469 | BRD-K74717603 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.44 | -1.48 | 15.35 |
| 127522 | BRD-K74717603 | JURKAT | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127559 | BRD-K74717603 | MCF10A | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127612 | BRD-K74717603 | PC3 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.31 | 1.09 | 0.67 |
| 127650 | BRD-K74717603 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127692 | BRD-K74717603 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135347 | BRD-K74717603 | A549 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.28 | 0.99 | 0.4 |
| 135408 | BRD-K74717603 | HT29 | 2.22 uM | 24 h | -0.28 | -1.16 | 0.46 | -0.3 | -1.01 | 0.57 |
| 135474 | BRD-K74717603 | MCF??7.00 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |