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CMap Candidate Details

Structure:
CMap ID: C02108
Pert ID: BRD-K48367671
Compound Name: febuxostat
Targets: XDH
MoA: xanthine oxidase inhibitor
SMILES: CC(C)COc1ccc(cc1C#N)-c1nc(C)c(s1)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3372 BRD-K48367671 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3964 BRD-K48367671 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45271 BRD-K48367671 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46091 BRD-K48367671 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46407 BRD-K48367671 PHH 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
46729 BRD-K48367671 SKB 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
125259 BRD-K48367671 A549 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
125317 BRD-K48367671 HEK293 1.11 uM 24 h 0.22 0.91 0.04 0.32 1.15 0.88
125400 BRD-K48367671 JURKAT 1.11 uM 24 h -0.24 -1.02 0.17 0.0 0.0 0.0
125448 BRD-K48367671 MCF??7.00 0.04 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
125521 BRD-K48367671 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
125549 BRD-K48367671 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133342 BRD-K48367671 A375 0.03 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.86
133391 BRD-K48367671 HA1E 0.08 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
133425 BRD-K48367671 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133458 BRD-K48367671 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133520 BRD-K48367671 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133556 BRD-K48367671 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133584 BRD-K48367671 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).