CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02112
Pert ID:	BRD-A30815329
Compound Name:	felodipine
Targets:	CACNA1C\|CACNA1D\|CACNA1F\|CACNA1H\|CACNA1S\|CACNA2D1\|CACNA2D2\|CACNB2\|CALM1\|CFTR\|NR3C2\|PDE1A\|PDE1B\|TNNC1\|TNNC2
MoA:	calcium channel blocker
SMILES:	CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4291	BRD-A30815329	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
4845	BRD-A30815329	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37473	BRD-A30815329	ASC	10 uM	24 h	0.0	0.0	0.0	0.36	1.29	1.49
37803	BRD-A30815329	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38323	BRD-A30815329	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38621	BRD-A30815329	PHH	10 uM	24 h	0.25	1.04	0.15	0.25	0.9	0.22
38841	BRD-A30815329	SKB	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
51560	BRD-A30815329	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91068	BRD-A30815329	HUH7	8 uM	72 h	0.0	0.0	0.0	-0.3	-1.03	0.62
121895	BRD-A30815329	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121917	BRD-A30815329	A549	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121958	BRD-A30815329	HEK293	0.37 uM	24 h	-0.35	-1.45	1.43	-0.36	-1.22	1.25
122050	BRD-A30815329	HUVEC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122167	BRD-A30815329	PC3	10 uM	24 h	-0.26	-1.09	0.32	0.0	0.0	0.0
122193	BRD-A30815329	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130229	BRD-A30815329	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130290	BRD-A30815329	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.34	1.19	1.03
130318	BRD-A30815329	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130351	BRD-A30815329	JURKAT	0.01 uM	24 h	0.24	1.0	0.1	0.25	0.87	0.17
130400	BRD-A30815329	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130450	BRD-A30815329	MDAMB231	0.08 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.84
130522	BRD-A30815329	YAPC	2.22 uM	24 h	0.18	0.76	0.0	-0.26	-0.88	0.25

Summary