CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02114
Pert ID:	BRD-K51318897
Compound Name:	fenbendazole
Targets:	TUBB
MoA:	tubulin polymerization inhibitor
SMILES:	COC(=O)Nc1nc2ccc(Sc3ccccc3)cc2[nH]1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2893	BRD-K51318897	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
3223	BRD-K51318897	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3824	BRD-K51318897	VCAP	10 uM	24 h	-0.22	-0.9	0.04	0.25	0.88	0.18
44416	BRD-K51318897	A375	10 uM	6 h	0.0	0.0	0.0	-0.33	-1.11	0.91
44984	BRD-K51318897	ASC	10 uM	24 h	0.0	0.0	0.0	0.29	1.04	0.54
45278	BRD-K51318897	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45545	BRD-K51318897	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
46100	BRD-K51318897	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46415	BRD-K51318897	PHH	10 uM	24 h	0.29	1.23	0.5	0.0	0.0	0.0
46739	BRD-K51318897	SKB	10 uM	24 h	-0.23	-0.98	0.12	0.0	0.0	0.0
51478	BRD-K51318897	PC3	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.9
91315	BRD-K51318897	HUH7	12 uM	72 h	-0.25	-1.04	0.21	-0.21	-0.7	0.03
95530	BRD-K51318897	A549	10 uM	6 h	-0.27	-1.13	0.4	-0.45	-1.51	15.35
95554	BRD-K51318897	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95696	BRD-K51318897	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary