CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02154
Pert ID:	BRD-K01095011
Compound Name:	finasteride
Targets:	AKR1D1\|SRD5A1\|SRD5A2
MoA:	5 alpha reductase inhibitor
SMILES:	CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4333	BRD-K01095011	HCC515	10 uM	24 h	-0.25	-1.04	0.21	0.0	0.0	0.0
24741	BRD-K01095011	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
24863	BRD-K01095011	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
24999	BRD-K01095011	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25228	BRD-K01095011	PC3	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25317	BRD-K01095011	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44276	BRD-K01095011	A375	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.92	0.34
44505	BRD-K01095011	A549	10 uM	24 h	0.0	0.0	0.0	0.27	0.94	0.3
44810	BRD-K01095011	ASC	10 uM	24 h	-0.21	-0.88	0.03	-0.33	-1.1	0.88
45126	BRD-K01095011	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45928	BRD-K01095011	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46561	BRD-K01095011	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91325	BRD-K01095011	HUH7	8 uM	72 h	-0.27	-1.14	0.42	0.22	0.78	0.07
99955	BRD-K01095011	U2OS	6.66 uM	6 h	0.22	0.92	0.04	0.29	1.04	0.56

Summary