CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02165
Pert ID:	BRD-K58550667
Compound Name:	FK-866
Targets:	NAMPT
MoA:	niacinamide phosphoribosyltransferase inhibitor
SMILES:	O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
9455	BRD-K58550667	AGS	0.08 uM	6 h	-0.23	-0.95	0.09	0.0	0.0	0.0
9761	BRD-K58550667	H1299	0.08 uM	6 h	0.25	1.06	0.18	0.0	0.0	0.0
11196	BRD-K58550667	MCF??7.00	0.08 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.7
11520	BRD-K58550667	NCIH2073	0.08 uM	6 h	0.0	0.0	0.0	0.25	0.87	0.17
11790	BRD-K58550667	NCIH508	0.08 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12083	BRD-K58550667	NCIH596	0.08 uM	6 h	0.34	1.43	1.12	0.0	0.0	0.0
12340	BRD-K58550667	NOMO1	0.08 uM	6 h	0.0	0.0	0.0	0.23	0.82	0.1
13642	BRD-K58550667	VCAP	0.08 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
98606	BRD-K58550667	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99061	BRD-K58550667	NEU	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
117367	BRD-K58550667	A549	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.98	0.49
117448	BRD-K58550667	HCC515	3.33 uM	24 h	0.37	1.56	1.49	0.0	0.0	0.0
117493	BRD-K58550667	HEPG2	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121720	BRD-K58550667	A375	10 uM	24 h	0.0	0.0	0.0	-0.41	-1.38	2.02
121761	BRD-K58550667	HELA	10 uM	24 h	0.0	0.0	0.0	0.4	1.42	2.19
129790	BRD-K58550667	HA1E	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129825	BRD-K58550667	HEK293	0.08 uM	24 h	0.32	1.32	0.78	0.0	0.0	0.0
129892	BRD-K58550667	HT29	0.08 uM	24 h	0.25	1.04	0.14	-0.25	-0.84	0.18
129952	BRD-K58550667	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130036	BRD-K58550667	MDAMB231	0.01 uM	24 h	0.23	0.95	0.06	0.0	0.0	0.0
130081	BRD-K58550667	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130108	BRD-K58550667	THP1	0.03 uM	24 h	0.24	0.98	0.09	0.0	0.0	0.0
130156	BRD-K58550667	YAPC	0.03 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.7

Summary