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CMap Candidate Details

Structure:
CMap ID: C02166
Pert ID: BRD-K83508485
Compound Name: FK-888
Targets: TACR1|TACR2
MoA: tachykinin antagonist
SMILES: CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1986 BRD-K83508485 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2433 BRD-K83508485 PC3 10 uM 6 h 0.22 0.93 0.05 0.26 0.92 0.25
2514 BRD-K83508485 VCAP 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
39790 BRD-K83508485 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40082 BRD-K83508485 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.31 1.09 0.67
40889 BRD-K83508485 NEU 10 uM 24 h -0.23 -0.96 0.1 0.22 0.77 0.06
41210 BRD-K83508485 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41549 BRD-K83508485 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125561 BRD-K83508485 A375 0.37 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
125603 BRD-K83508485 A549 10 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
125665 BRD-K83508485 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.87
125689 BRD-K83508485 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125709 BRD-K83508485 HUVEC 10 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
125762 BRD-K83508485 JURKAT 0.125 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
125817 BRD-K83508485 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125841 BRD-K83508485 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125886 BRD-K83508485 THP1 1.11 uM 24 h -0.41 -1.71 15.65 -0.32 -1.07 0.75
125908 BRD-K83508485 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133683 BRD-K83508485 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133723 BRD-K83508485 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133842 BRD-K83508485 MCF10A 0.74 uM 24 h -0.25 -1.05 0.23 0.24 0.86 0.16
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).