CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02170
Pert ID:	BRD-A09472452
Compound Name:	flecainide
Targets:	KCNA5\|KCNA7\|SCN4A\|SCN5A
MoA:	sodium channel blocker
SMILES:	FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5494	BRD-A09472452	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5823	BRD-A09472452	HEPG2	10 uM	6 h	0.25	1.04	0.14	0.0	0.0	0.0
42169	BRD-A09472452	ASC	10 uM	24 h	-0.26	-1.06	0.26	0.0	0.0	0.0
43373	BRD-A09472452	NPC	10 uM	24 h	0.25	1.05	0.16	-0.25	-0.83	0.17
43688	BRD-A09472452	PHH	10 uM	24 h	0.27	1.11	0.25	0.27	0.96	0.34
49930	BRD-A09472452	A549	10 uM	6 h	0.0	0.0	0.0	-0.36	-1.21	1.24
50094	BRD-A09472452	HA1E	10 uM	6 h	0.0	0.0	0.0	0.35	1.24	1.28
50448	BRD-A09472452	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50625	BRD-A09472452	MCF??7.00	10 uM	24 h	0.18	0.77	0.0	-0.38	-1.27	1.41
50880	BRD-A09472452	PC3	10 uM	6 h	0.0	0.0	0.0	0.32	1.15	0.88
50971	BRD-A09472452	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90986	BRD-A09472452	HUH7	8 uM	72 h	-0.29	-1.19	0.55	0.0	0.0	0.0
121348	BRD-A09472452	YAPC	10 uM	24 h	0.0	0.0	0.0	-0.37	-1.23	1.27
129246	BRD-A09472452	A375	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129276	BRD-A09472452	HELA	0.74 uM	3 h	0.0	0.0	0.0	-0.33	-1.12	0.93

Summary