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CMap Candidate Details

Structure:
CMap ID: C02182
Pert ID: BRD-K05977355
Compound Name: fluconazole
Targets: CYP51A1
MoA: sterol demethylase inhibitor
SMILES: OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4539 BRD-K05977355 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37364 BRD-K05977355 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37584 BRD-K05977355 ASC 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
38419 BRD-K05977355 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51121 BRD-K05977355 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
52894 BRD-K05977355 HEPG2 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91362 BRD-K05977355 HUH7 10 uM 72 h 0.0 0.0 0.0 -0.2 -0.68 0.02
100002 BRD-K05977355 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
122597 BRD-K05977355 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122629 BRD-K05977355 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122677 BRD-K05977355 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122712 BRD-K05977355 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
122749 BRD-K05977355 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122768 BRD-K05977355 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
130865 BRD-K05977355 A375 0.01 uM 24 h -0.29 -1.21 0.59 -0.22 -0.74 0.05
130960 BRD-K05977355 HELA 0.01 uM 24 h 0.28 1.15 0.32 0.41 1.44 2.21
131034 BRD-K05977355 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131145 BRD-K05977355 PC3 0.03 uM 24 h 0.28 1.18 0.39 0.21 0.73 0.03
131178 BRD-K05977355 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).