CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02185
Pert ID:	BRD-K71106091
Compound Name:	fludarabine-phosphate
Targets:	DCK\|POLA1\|POLD1\|POLE\|RRM1\|RRM2\|RRM2B
MoA:	ribonucleotide reductase inhibitor
SMILES:	Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
117336	BRD-K71106091	A375	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.84	0.18
117458	BRD-K71106091	HCC515	10 uM	24 h	0.27	1.11	0.26	0.0	0.0	0.0
117505	BRD-K71106091	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126724	BRD-K71106091	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126807	BRD-K71106091	MCF10A	10 uM	24 h	-0.22	-0.9	0.04	0.0	0.0	0.0
126847	BRD-K71106091	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29
126891	BRD-K71106091	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.17	0.6	0.0
126917	BRD-K71106091	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126959	BRD-K71106091	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134706	BRD-K71106091	A549	2.22 uM	24 h	0.0	0.0	0.0	-0.22	-0.73	0.05
134734	BRD-K71106091	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134769	BRD-K71106091	HEK293	2.22 uM	24 h	0.27	1.13	0.29	0.0	0.0	0.0
134830	BRD-K71106091	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134873	BRD-K71106091	HUVEC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134901	BRD-K71106091	JURKAT	2.22 uM	24 h	0.26	1.07	0.2	0.25	0.87	0.18
134995	BRD-K71106091	YAPC	0.25 uM	24 h	0.26	1.1	0.24	0.0	0.0	0.0

Summary