CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02189
Pert ID:	BRD-K68870568
Compound Name:	flumatinib
Targets:	ABL1\|PDGFRB
MoA:	Bcr-Abl kinase inhibitor
SMILES:	CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2cnc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
95337	BRD-K68870568	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95373	BRD-K68870568	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95465	BRD-K68870568	U2OS	1.11 uM	6 h	-0.31	-1.27	0.74	0.0	0.0	0.0
96693	BRD-K68870568	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126739	BRD-K68870568	HT29	10 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.43
126768	BRD-K68870568	JURKAT	10 uM	24 h	-0.24	-0.98	0.12	0.3	1.07	0.63
126800	BRD-K68870568	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.33	1.18	0.99
126878	BRD-K68870568	MDAMB231	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126940	BRD-K68870568	THP1	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.93
134671	BRD-K68870568	A375	2.22 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.27
134722	BRD-K68870568	HA1E	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134759	BRD-K68870568	HEK293	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134792	BRD-K68870568	HELA	0.08 uM	24 h	0.0	0.0	0.0	-0.2	-0.69	0.02
134855	BRD-K68870568	HUVEC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134988	BRD-K68870568	YAPC	0.74 uM	24 h	-0.22	-0.91	0.05	0.0	0.0	0.0

Summary