CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02190
Pert ID:	BRD-K98769987
Compound Name:	flumazenil
Targets:	GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ
MoA:	benzodiazepine receptor antagonist
SMILES:	CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3421	BRD-K98769987	HCC515	10 uM	6 h	0.0	0.0	0.0	0.26	0.91	0.23
25460	BRD-K98769987	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41859	BRD-K98769987	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42503	BRD-K98769987	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42812	BRD-K98769987	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.25	-0.84	0.18
43677	BRD-K98769987	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44225	BRD-K98769987	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90930	BRD-K98769987	HUH7	10 uM	72 h	0.0	0.0	0.0	0.27	0.95	0.31
127794	BRD-K98769987	A549	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127877	BRD-K98769987	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127951	BRD-K98769987	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128003	BRD-K98769987	MCF10A	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135529	BRD-K98769987	HA1E	2.22 uM	24 h	-0.23	-0.97	0.11	0.0	0.0	0.0
135578	BRD-K98769987	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135620	BRD-K98769987	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135669	BRD-K98769987	JURKAT	0.74 uM	24 h	0.0	0.0	0.0	-0.21	-0.71	0.04
135701	BRD-K98769987	MCF??7.00	2.22 uM	24 h	-0.16	-0.66	0.0	0.0	0.0	0.0
135725	BRD-K98769987	PC3	0.74 uM	24 h	0.22	0.93	0.05	0.2	0.71	0.02
135748	BRD-K98769987	YAPC	0.03 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.03

Summary