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CMap Candidate Details

Structure:
CMap ID: C02218
Pert ID: BRD-K77947974
Compound Name: fluspirilene
Targets: CACNG1|DRD2|HRH1|HTR1A|HTR1D|HTR1E|HTR2A
MoA: dopamine receptor antagonist
SMILES: Fc1ccc(cc1)C(CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9508 BRD-K77947974 AGS 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9812 BRD-K77947974 H1299 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10128 BRD-K77947974 HCC515 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10594 BRD-K77947974 HCT116 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11838 BRD-K77947974 NCIH508 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12131 BRD-K77947974 NCIH596 4 uM 6 h -0.19 -0.8 0.0 0.0 0.0 0.0
12868 BRD-K77947974 SW480 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13360 BRD-K77947974 U937 4 uM 6 h -0.18 -0.76 0.0 0.0 0.0 0.0
13680 BRD-K77947974 VCAP 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44728 BRD-K77947974 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45032 BRD-K77947974 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45321 BRD-K77947974 HEPG2 10 uM 6 h 0.23 0.94 0.06 -0.32 -1.09 0.83
46461 BRD-K77947974 PHH 10 uM 24 h 0.3 1.26 0.56 0.0 0.0 0.0
46785 BRD-K77947974 SKB 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
90949 BRD-K77947974 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99090 BRD-K77947974 NEU 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.7 0.03
99179 BRD-K77947974 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99501 BRD-K77947974 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
127029 BRD-K77947974 A375 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
127050 BRD-K77947974 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127112 BRD-K77947974 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127148 BRD-K77947974 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127218 BRD-K77947974 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127251 BRD-K77947974 PC3 10 uM 24 h 0.0 0.0 0.0 0.39 1.38 2.15
127289 BRD-K77947974 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.46
135112 BRD-K77947974 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
135182 BRD-K77947974 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
135215 BRD-K77947974 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135280 BRD-K77947974 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135332 BRD-K77947974 YAPC 2.22 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).