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CMap Candidate Details

Structure:
CMap ID: C02220
Pert ID: BRD-K62310379
Compound Name: fluticasone-propionate
Targets: NR3C1|NR3C2|PGR|PLA2G4A
MoA: glucocorticoid receptor agonist
SMILES: CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2109 BRD-K62310379 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2551 BRD-K62310379 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42421 BRD-K62310379 ASC 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
42737 BRD-K62310379 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43602 BRD-K62310379 NPC 10 uM 24 h 0.0 0.0 0.0 0.19 0.68 0.01
95975 BRD-K62310379 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99305 BRD-K62310379 U2OS 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124928 BRD-K62310379 A375 0.04 uM 24 h 0.22 0.91 0.03 -0.31 -1.04 0.66
124956 BRD-K62310379 A549 0.04 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
125017 BRD-K62310379 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125048 BRD-K62310379 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125092 BRD-K62310379 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125147 BRD-K62310379 THP1 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.72
125196 BRD-K62310379 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133007 BRD-K62310379 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
133033 BRD-K62310379 HEK293 0.74 uM 24 h -0.18 -0.77 0.0 -0.24 -0.8 0.12
133140 BRD-K62310379 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
133188 BRD-K62310379 MCF10A 0.74 uM 24 h 0.18 0.75 0.0 -0.29 -0.99 0.5
133254 BRD-K62310379 MDAMB231 0.25 uM 24 h -0.29 -1.21 0.58 0.0 0.0 0.0
133282 BRD-K62310379 PC3 0.01 uM 24 h 0.38 1.59 1.53 0.27 0.97 0.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).