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CMap Candidate Details

Structure:
CMap ID: C02228
Pert ID: BRD-K03449891
Compound Name: foretinib
Targets: FLT1|FLT4|KDR|MET
MoA: VEGFR inhibitor
SMILES: COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91873 BRD-K03449891 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.29 1.02 0.47
92020 BRD-K03449891 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92100 BRD-K03449891 HCC515 10 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.19
92158 BRD-K03449891 HS578T 10 uM 3 h 0.0 0.0 0.0 0.27 0.96 0.33
92231 BRD-K03449891 MCF10A 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92289 BRD-K03449891 MDAMB231 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92339 BRD-K03449891 PC3 0.12 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.77
92367 BRD-K03449891 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95449 BRD-K03449891 U2OS 10 uM 6 h 0.0 0.0 0.0 0.21 0.74 0.04
122844 BRD-K03449891 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122870 BRD-K03449891 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122924 BRD-K03449891 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123049 BRD-K03449891 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
123209 BRD-K03449891 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131265 BRD-K03449891 A549 2.22 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
131319 BRD-K03449891 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131332 BRD-K03449891 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.12
131386 BRD-K03449891 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131519 BRD-K03449891 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).