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CMap Candidate Details

Structure:
CMap ID: C02258
Pert ID: BRD-K68756823
Compound Name: FR-180204
Targets: MAPK1|MAPK3
MoA: MAP kinase inhibitor
SMILES: Nc1[nH]nc2nnc(cc12)-c1c(nn2ccccc12)-c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
20082 BRD-K68756823 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20732 BRD-K68756823 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
21113 BRD-K68756823 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.2 0.71 0.02
21617 BRD-K68756823 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91824 BRD-K68756823 HS578T 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91946 BRD-K68756823 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92876 BRD-K68756823 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92903 BRD-K68756823 A549 10 uM 24 h -0.28 -1.15 0.43 -0.2 -0.69 0.02
92961 BRD-K68756823 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93012 BRD-K68756823 CD34 0.12 uM 24 h 0.2 0.82 0.0 0.0 0.0 0.0
93051 BRD-K68756823 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93099 BRD-K68756823 HEK293 10 uM 24 h -0.17 -0.71 0.0 0.0 0.0 0.0
93140 BRD-K68756823 HELA 10 uM 24 h 0.22 0.92 0.04 0.31 1.1 0.69
93182 BRD-K68756823 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93238 BRD-K68756823 HUVEC 0.04 uM 24 h 0.21 0.86 0.01 -0.4 -1.36 2.02
93290 BRD-K68756823 JURKAT 10 uM 24 h 0.3 1.24 0.53 0.25 0.89 0.2
93326 BRD-K68756823 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
93369 BRD-K68756823 MDAMB231 1.11 uM 24 h -0.25 -1.04 0.21 -0.16 -0.53 0.0
93402 BRD-K68756823 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93457 BRD-K68756823 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93516 BRD-K68756823 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
93554 BRD-K68756823 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
93595 BRD-K68756823 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).