CMap Candidate Details
Structure:
| CMap ID: | C02313 |
| Pert ID: | BRD-K68938568 |
| Compound Name: | GDC-0152 |
| Targets: | BIRC2|BIRC3|BIRC7|XIAP |
| MoA: | XIAP inhibitor |
| SMILES: | CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)Nc1snnc1-c1ccccc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 126365 | BRD-K68938568 | A375 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.3 | 1.06 | 0.59 |
| 126406 | BRD-K68938568 | HA1E | 10 uM | 24 h | -0.26 | -1.1 | 0.35 | -0.23 | -0.78 | 0.09 |
| 126450 | BRD-K68938568 | HEK293 | 10 uM | 24 h | -0.18 | -0.76 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126528 | BRD-K68938568 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.95 | 0.4 |
| 126611 | BRD-K68938568 | YAPC | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134381 | BRD-K68938568 | A549 | 2.22 uM | 24 h | -0.32 | -1.33 | 0.92 | -0.4 | -1.33 | 1.85 |
| 134437 | BRD-K68938568 | HELA | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.3 | -0.99 | 0.51 |
| 134471 | BRD-K68938568 | HT29 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.21 | 1.24 |
| 134517 | BRD-K68938568 | HUVEC | 0.01 uM | 24 h | 0.29 | 1.2 | 0.44 | 0.0 | 0.0 | 0.0 |
| 134574 | BRD-K68938568 | MCF??7.00 | 0.08 uM | 24 h | -0.21 | -0.86 | 0.02 | 0.0 | 0.0 | 0.0 |
| 134606 | BRD-K68938568 | MDAMB231 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134631 | BRD-K68938568 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.41 | -1.37 | 2.02 |