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CMap Candidate Details

Structure:
CMap ID: C02323
Pert ID: BRD-K64052750
Compound Name: gefitinib
Targets: EGFR
MoA: EGFR inhibitor
SMILES: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1320 BRD-K64052750 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.52
34144 BRD-K64052750 ASC 10 uM 24 h -0.3 -1.26 0.71 0.0 0.0 0.0
35595 BRD-K64052750 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35815 BRD-K64052750 NPC 10 uM 24 h -0.25 -1.05 0.24 -0.29 -0.96 0.44
36306 BRD-K64052750 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36604 BRD-K64052750 SKB 10 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.49
36847 BRD-K64052750 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87306 BRD-K64052750 BJAB 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87359 BRD-K64052750 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87409 BRD-K64052750 K562 10 uM 24 h -0.29 -1.22 0.62 -0.26 -0.86 0.21
87457 BRD-K64052750 KMS34 10 uM 24 h 0.0 0.0 0.0 0.26 0.9 0.23
87486 BRD-K64052750 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87561 BRD-K64052750 NALM6 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
87611 BRD-K64052750 OCILY10 10 uM 24 h 0.17 0.71 0.0 0.0 0.0 0.0
87662 BRD-K64052750 OCILY19 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
87713 BRD-K64052750 OCILY3 10 uM 24 h 0.18 0.75 0.0 -0.35 -1.17 1.12
87760 BRD-K64052750 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87805 BRD-K64052750 THP1 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87870 BRD-K64052750 TMD8 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90934 BRD-K64052750 HUH7 8 uM 72 h 0.0 0.0 0.0 0.31 1.09 0.67
92481 BRD-K64052750 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.43 1.54 2.31
92568 BRD-K64052750 HME1 10 uM 3 h 0.0 0.0 0.0 -0.27 -0.9 0.28
92612 BRD-K64052750 HS578T 0.12 uM 3 h -0.28 -1.16 0.45 -0.23 -0.78 0.1
92684 BRD-K64052750 LNCAP 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
92751 BRD-K64052750 MCF10A 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92838 BRD-K64052750 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115623 BRD-K64052750 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115740 BRD-K64052750 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.49
115782 BRD-K64052750 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115829 BRD-K64052750 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115910 BRD-K64052750 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124968 BRD-K64052750 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125000 BRD-K64052750 HA1E 10 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
125030 BRD-K64052750 HELA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125097 BRD-K64052750 MCF??7.00 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
125113 BRD-K64052750 MDAMB231 3.33 uM 24 h -0.21 -0.89 0.04 0.0 0.0 0.0
125209 BRD-K64052750 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133053 BRD-K64052750 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133160 BRD-K64052750 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.36
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).