CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00236
Pert ID:	BRD-K92000912
Compound Name:	AM-251
Targets:	CNR1\|GPR18\|GPR55
MoA:	cannabinoid receptor antagonist
SMILES:	Cc1c(nn(c1-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2943	BRD-K92000912	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3409	BRD-K92000912	HCC515	10 uM	6 h	0.28	1.15	0.34	0.0	0.0	0.0
3562	BRD-K92000912	PC3	10 uM	24 h	0.26	1.08	0.22	0.32	1.13	0.84
3892	BRD-K92000912	VCAP	10 uM	24 h	-0.3	-1.26	0.72	0.24	0.86	0.16
22005	BRD-K92000912	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
22356	BRD-K92000912	A549	10 uM	6 h	0.24	0.99	0.1	0.0	0.0	0.0
23188	BRD-K92000912	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.89	0.27
23476	BRD-K92000912	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
23654	BRD-K92000912	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39825	BRD-K92000912	ASC	10 uM	24 h	0.26	1.07	0.2	-0.26	-0.86	0.21
40923	BRD-K92000912	NEU	10 uM	24 h	-0.22	-0.9	0.05	-0.36	-1.23	1.25
41247	BRD-K92000912	NPC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.3
41588	BRD-K92000912	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary