CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02361
Pert ID:	BRD-K34776109
Compound Name:	glimepiride
Targets:	ABCC8\|KCNJ1\|KCNJ11
MoA:	insulin secretagogue
SMILES:	CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]2CC[C@H](C)CC2)C1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4419	BRD-K34776109	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5077	BRD-K34776109	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.06	0.75
37640	BRD-K34776109	ASC	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.67
38466	BRD-K34776109	NPC	10 uM	24 h	0.29	1.21	0.46	0.0	0.0	0.0
38712	BRD-K34776109	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91401	BRD-K34776109	HUH7	6.66 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
96426	BRD-K34776109	PC3	10 uM	24 h	0.0	0.0	0.0	0.29	1.03	0.52
120529	BRD-K34776109	A375	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.25
120566	BRD-K34776109	A549	1.11 uM	24 h	0.33	1.36	0.97	0.0	0.0	0.0
120605	BRD-K34776109	HA1E	0.04 uM	24 h	0.0	0.0	0.0	0.25	0.9	0.22
120671	BRD-K34776109	HT29	10 uM	24 h	0.0	0.0	0.0	0.33	1.16	0.9
120724	BRD-K34776109	JURKAT	10 uM	24 h	-0.28	-1.15	0.44	0.0	0.0	0.0
120832	BRD-K34776109	YAPC	3.33 uM	24 h	0.21	0.88	0.02	0.0	0.0	0.0
129038	BRD-K34776109	HELA	0.03 uM	3 h	0.0	0.0	0.0	-0.27	-0.92	0.32
129059	BRD-K34776109	MCF??7.00	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary