CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02362
Pert ID:	BRD-K12219985
Compound Name:	glipizide
Targets:	ABCC8\|KCNJ10\|KCNJ11\|PPARG
MoA:	sulfonylurea
SMILES:	Cc1cnc(cn1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4364	BRD-K12219985	HCC515	10 uM	24 h	-0.16	-0.67	0.0	-0.37	-1.25	1.35
4894	BRD-K12219985	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37594	BRD-K12219985	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37873	BRD-K12219985	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38429	BRD-K12219985	NPC	10 uM	24 h	0.0	0.0	0.0	0.43	1.54	2.31
38913	BRD-K12219985	SKB	10 uM	24 h	0.0	0.0	0.0	0.32	1.12	0.76
90955	BRD-K12219985	HUH7	8 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
100091	BRD-K12219985	U2OS	12 uM	6 h	-0.24	-1.0	0.15	-0.33	-1.11	0.9
122234	BRD-K12219985	A375	0.04 uM	24 h	0.24	0.99	0.1	0.0	0.0	0.0
122277	BRD-K12219985	A549	1.11 uM	24 h	-0.24	-0.98	0.13	0.0	0.0	0.0
122291	BRD-K12219985	HA1E	3.33 uM	24 h	-0.22	-0.92	0.06	-0.36	-1.21	1.23
122380	BRD-K12219985	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122456	BRD-K12219985	THP1	10 uM	24 h	0.26	1.1	0.24	-0.31	-1.06	0.73
130609	BRD-K12219985	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.39	1.38	2.16
130650	BRD-K12219985	HELA	0.08 uM	24 h	0.27	1.13	0.29	0.0	0.0	0.0
130690	BRD-K12219985	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130731	BRD-K12219985	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130775	BRD-K12219985	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	0.38	1.35	1.72
130802	BRD-K12219985	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130825	BRD-K12219985	YAPC	0.01 uM	24 h	0.22	0.94	0.05	-0.41	-1.38	2.02

Summary