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CMap Candidate Details

Structure:
CMap ID: C02385
Pert ID: BRD-K69001009
Compound Name: golvatinib
Targets: KDR|MET
MoA: VEGFR inhibitor
SMILES: CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)c(F)c2)ccn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126627 BRD-K69001009 A375 10 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
126649 BRD-K69001009 A549 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
126712 BRD-K69001009 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126740 BRD-K69001009 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126769 BRD-K69001009 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126801 BRD-K69001009 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126835 BRD-K69001009 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126879 BRD-K69001009 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126910 BRD-K69001009 PC3 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
126941 BRD-K69001009 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126987 BRD-K69001009 YAPC 10 uM 24 h 0.0 0.0 0.0 0.38 1.33 1.72
134723 BRD-K69001009 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134760 BRD-K69001009 HEK293 0.08 uM 24 h -0.2 -0.84 0.01 -0.37 -1.25 1.35
134856 BRD-K69001009 HUVEC 2.22 uM 24 h 0.24 0.99 0.09 -0.3 -1.02 0.62
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).