Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C02416
Pert ID: BRD-K76719364
Compound Name: GS-9973
Targets: SYK
MoA: syk inhibitor
SMILES: C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
56 BRD-K76719364 BJAB 2.5 uM 4 h 0.0 0.0 0.0 0.3 1.06 0.59
90 BRD-K76719364 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127 BRD-K76719364 K562 0.04 uM 24 h 0.22 0.93 0.04 0.0 0.0 0.0
179 BRD-K76719364 KMS34 10 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
220 BRD-K76719364 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
259 BRD-K76719364 OCILY10 10 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
312 BRD-K76719364 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
334 BRD-K76719364 OCILY3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
378 BRD-K76719364 SKMEL5 10 uM 24 h -0.19 -0.79 0.0 0.36 1.26 1.29
423 BRD-K76719364 THP1 0.04 uM 4 h 0.0 0.0 0.0 0.22 0.78 0.07
463 BRD-K76719364 TMD8 2.5 uM 4 h 0.31 1.28 0.6 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).