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CMap Candidate Details

Structure:
CMap ID: C02426
Pert ID: BRD-K04923131
Compound Name: GSK-3-inhibitor-IX
Targets: GSK3A|GSK3B
MoA: glycogen synthase kinase inhibitor; lipoxygenase inhibitor
SMILES: O\N=C1/C(Nc2ccccc12)=C1/C(=O)Nc2cc(Br)ccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33887 BRD-K04923131 A549 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.43
34030 BRD-K04923131 ASC 10 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.01
34543 BRD-K04923131 HCC515 10 uM 6 h -0.17 -0.72 0.0 -0.35 -1.19 1.16
34813 BRD-K04923131 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35080 BRD-K04923131 HT29 10 uM 6 h 0.17 0.71 0.0 -0.35 -1.19 1.15
35379 BRD-K04923131 MCF??7.00 10 uM 6 h 0.16 0.67 0.0 0.0 0.0 0.0
36054 BRD-K04923131 PC3 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.33 1.81
36186 BRD-K04923131 PHH 10 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
36479 BRD-K04923131 SKB 10 uM 24 h 0.31 1.29 0.66 0.22 0.77 0.06
36941 BRD-K04923131 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91530 BRD-K04923131 BT20 0.37 uM 6 h 0.32 1.31 0.78 -0.24 -0.8 0.12
91569 BRD-K04923131 HS578T 10 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
91616 BRD-K04923131 MCF10A 10 uM 24 h 0.32 1.34 0.89 0.0 0.0 0.0
91682 BRD-K04923131 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91765 BRD-K04923131 SKBR3 10 uM 6 h 0.22 0.93 0.05 0.24 0.85 0.14
97320 BRD-K04923131 HAP1 3.33 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
98741 BRD-K04923131 NPC 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
98862 BRD-K04923131 NEU 10 uM 24 h 0.2 0.84 0.0 0.24 0.86 0.16
118380 BRD-K04923131 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118451 BRD-K04923131 HA1E 3.33 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).