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CMap Candidate Details

Structure:
CMap ID: C02429
Pert ID: BRD-K36740062
Compound Name: GSK1070916
Targets: AURKA|AURKB|AURKC|CYP2D6|CYP3A4
MoA: Aurora kinase inhibitor
SMILES: CCn1cc(c(n1)-c1ccc(NC(=O)N(C)C)cc1)-c1ccnc2[nH]c(cc12)-c1cccc(CN(C)C)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
35563 BRD-K36740062 NEU 10 uM 24 h 0.22 0.9 0.02 -0.31 -1.06 0.73
36255 BRD-K36740062 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36550 BRD-K36740062 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36963 BRD-K36740062 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91542 BRD-K36740062 BT20 10 uM 6 h 0.22 0.92 0.04 0.0 0.0 0.0
91574 BRD-K36740062 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91649 BRD-K36740062 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91687 BRD-K36740062 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91771 BRD-K36740062 SKBR3 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
93607 BRD-K36740062 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93638 BRD-K36740062 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93695 BRD-K36740062 CD34 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
93781 BRD-K36740062 HCC515 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
93821 BRD-K36740062 HEK293 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.49
93872 BRD-K36740062 HELA 3.33 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
93912 BRD-K36740062 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93981 BRD-K36740062 HUVEC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94008 BRD-K36740062 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
94151 BRD-K36740062 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94218 BRD-K36740062 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94271 BRD-K36740062 SKL 10 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
94321 BRD-K36740062 THP1 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
121834 BRD-K36740062 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129749 BRD-K36740062 A375 2.22 uM 24 h 0.32 1.34 0.89 0.27 0.96 0.34
129782 BRD-K36740062 HA1E 0.74 uM 24 h 0.34 1.41 1.03 0.0 0.0 0.0
129890 BRD-K36740062 HT29 2.22 uM 24 h -0.16 -0.66 0.0 0.0 0.0 0.0
129939 BRD-K36740062 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
130147 BRD-K36740062 YAPC 2.22 uM 24 h 0.34 1.4 1.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).