CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02432
Pert ID:	BRD-K06749501
Compound Name:	GSK1838705A
Targets:	ALK\|IGF1R\|INSR\|RPS6KA1
MoA:	insulin growth factor receptor inhibitor
SMILES:	CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
496	BRD-K06749501	BJAB	10 uM	24 h	0.24	0.98	0.09	-0.34	-1.16	1.1
535	BRD-K06749501	HBL1	10 uM	24 h	0.23	0.98	0.09	-0.25	-0.84	0.17
599	BRD-K06749501	K562	10 uM	4 h	0.0	0.0	0.0	0.0	0.0	0.0
634	BRD-K06749501	KMS34	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
680	BRD-K06749501	MINO	10 uM	24 h	0.32	1.32	0.78	0.0	0.0	0.0
727	BRD-K06749501	NALM6	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
762	BRD-K06749501	OCILY19	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
832	BRD-K06749501	OCILY3	0.125 uM	4 h	-0.26	-1.09	0.33	-0.31	-1.03	0.64
869	BRD-K06749501	SKMEL5	0.04 uM	24 h	-0.22	-0.94	0.07	0.0	0.0	0.0
911	BRD-K06749501	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
939	BRD-K06749501	TMD8	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.2	1.22
90863	BRD-K06749501	MCF10A	1.11 uM	24 h	-0.18	-0.76	0.0	0.0	0.0	0.0
97333	BRD-K06749501	HAP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97354	BRD-K06749501	A375	0.66 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.33

Summary