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CMap Candidate Details

Structure:
CMap ID: C02453
Pert ID: BRD-A10523515
Compound Name: GSK429286A
Targets: ROCK1
MoA: rho associated kinase inhibitor
SMILES: CC1=C(C(CC(=O)N1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1cc2cn[nH]c2cc1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29710 BRD-A10523515 A375 10 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.27
32873 BRD-A10523515 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33396 BRD-A10523515 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91529 BRD-A10523515 BT20 10 uM 6 h 0.25 1.06 0.19 0.0 0.0 0.0
91594 BRD-A10523515 HS578T 10 uM 6 h 0.21 0.88 0.02 0.31 1.1 0.7
91705 BRD-A10523515 MDAMB231 10 uM 6 h -0.24 -1.02 0.17 0.29 1.03 0.52
91761 BRD-A10523515 SKBR3 10 uM 6 h -0.23 -0.95 0.09 -0.33 -1.12 0.94
94502 BRD-A10523515 ASC 0.12 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
94525 BRD-A10523515 CD34 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94620 BRD-A10523515 HEK293 1.11 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
94670 BRD-A10523515 HELA 0.12 uM 24 h 0.0 0.0 0.0 0.21 0.74 0.04
94718 BRD-A10523515 HME1 10 uM 24 h -0.29 -1.2 0.55 0.29 1.04 0.55
94813 BRD-A10523515 HUVEC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94867 BRD-A10523515 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94919 BRD-A10523515 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
94962 BRD-A10523515 MCF??7.00 0.04 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
94994 BRD-A10523515 NEU 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95066 BRD-A10523515 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95101 BRD-A10523515 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95138 BRD-A10523515 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.5
95225 BRD-A10523515 SKL 0.12 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
95252 BRD-A10523515 THP1 0.04 uM 24 h -0.25 -1.02 0.18 -0.27 -0.9 0.29
117028 BRD-A10523515 A549 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
117069 BRD-A10523515 HA1E 3.33 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
117103 BRD-A10523515 HCC515 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
117152 BRD-A10523515 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117197 BRD-A10523515 HT29 3.33 uM 24 h -0.24 -1.01 0.16 -0.29 -0.97 0.45
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).