CMap Candidate Details
Structure:
| CMap ID: | C02457 |
| Pert ID: | BRD-K25325018 |
| Compound Name: | GSK690693 |
| Targets: | AKT1|AKT2|AKT3|PAK4|PAK6|PAK7|PRKCQ|PRKG1|PRKX |
| MoA: | AKT inhibitor |
| SMILES: | CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 115237 | BRD-K25325018 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 115284 | BRD-K25325018 | A549 | 10 uM | 24 h | -0.22 | -0.9 | 0.04 | 0.0 | 0.0 | 0.0 |
| 115331 | BRD-K25325018 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 115379 | BRD-K25325018 | HCC515 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 115431 | BRD-K25325018 | HEPG2 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.99 | 0.5 |
| 115481 | BRD-K25325018 | HT29 | 10 uM | 24 h | -0.19 | -0.78 | 0.0 | -0.3 | -1.02 | 0.62 |
| 115532 | BRD-K25325018 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.06 | 0.74 |
| 115581 | BRD-K25325018 | PC3 | 3.33 uM | 24 h | 0.26 | 1.09 | 0.22 | 0.0 | 0.0 | 0.0 |