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CMap Candidate Details

Structure:
CMap ID: C00246
Pert ID: BRD-K56558538
Compound Name: ambroxol
Targets: CYP3A4
MoA: sodium channel blocker
SMILES: Nc1c(Br)cc(Br)cc1CN[C@H]1CC[C@H](O)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5343 BRD-K56558538 HA1E 10 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
5652 BRD-K56558538 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5931 BRD-K56558538 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.79 0.11
6572 BRD-K56558538 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37299 BRD-K56558538 A549 10 uM 24 h -0.29 -1.2 0.57 -0.37 -1.24 1.31
37697 BRD-K56558538 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38518 BRD-K56558538 NPC 10 uM 24 h 0.27 1.13 0.28 -0.31 -1.04 0.67
38976 BRD-K56558538 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51485 BRD-K56558538 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90958 BRD-K56558538 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99683 BRD-K56558538 U2OS 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123556 BRD-K56558538 HEK293 0.125 uM 24 h 0.3 1.24 0.53 0.0 0.0 0.0
123637 BRD-K56558538 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123675 BRD-K56558538 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.21 -0.69 0.02
131970 BRD-K56558538 A375 0.74 uM 24 h 0.21 0.89 0.02 0.32 1.14 0.86
132028 BRD-K56558538 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132071 BRD-K56558538 MCF??7.00 0.01 uM 24 h 0.29 1.23 0.5 -0.34 -1.15 1.08
132130 BRD-K56558538 YAPC 2.22 uM 24 h -0.21 -0.87 0.02 -0.32 -1.08 0.78
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).